Sequential Biomarker Evaluation and Risk Prediction for Alzheimer Disease

 
   Lead Investigator:    Dandan Liu
   Institution      :    Vanderbilt University
   E-Mail           :    dandan.liu@vanderbilt.edu
   Proposal ID      :    412



   Proposal Description:
   Neuroimaging and CSF biomarkers for AD were shown to be promising biomarkers for early detection of Alzheimer's Disease. However, they are costly and could not be administered to every patient. In addition, little is known about their utility when combined with other known risk factors. This project aims to sequentially evaluate accuracy measures and incremental values of 1)clinic risk factors at primary care provider level 2)neuropsycological and behavior assessment at specialty level 3)novel imaging and CSF biomarkers, in predicting conversion to AD.